Ciplox (Ciprofloxacin Hydrochloride), a fluoroquinolone, is a synthetic broad spectrum antibacterial agent for oral administration. It is a faintly yellowish to light yellow crystalline substance.
Ciplox is available in film coated tablets in strengths of 100, 250, 500 and 750 mg. Ciprofloxacin tablets are white to slightly yellowish in color.Ciplox is manufactured by Cipla Ltd., India.
Ciplox Tablets are indicated for the treatment of infections caused by susceptible strains of the designated bacteria in the conditions listed below
Ciplox Tablets (Ciprofloxacin) are contraindicated in patients that have hypersensitivity to ciprofloxacin, or any inactive ingredient present in Ciplox Tablets. They are also contraindicated in patients with a Hypersensitivity to fluoroquinolones or the quinolone class of antibacterial agents.
Given below are the warnings and precautions to be taken when using Ciplox Tablets (Ciprofloxacin): Drug Interactions:
Theophylline: Serum concentrations and elimination halflife of theophylline may be increased when it is used concurrently with ciprofloxacin. Theophylline doses should be reduced and plasma levels monitored.
Antacids: Antacids containing magnesium hydroxide and/or aluminium hydroxide may interfere with the absorption of ciprofloxacin, resulting in lower serum and urine levels; concurrent administration of antacids with ciprofloxacin should be avoided.
Anticoagulants: Prolongation of bleeding time has been reported during concomitant administration of ciprofloxacin and anticoagulants.
Cyclosporin: Transient increases in serum creatinine have been seen following concomitant administration of cyclosporin and ciprofloxacin.
Caffeine: Ciprofloxacin may interfere with the metabolism of caffeine, resulting in reduced clearance of caffeine.
Should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus. The safety and effectiveness of ciprofloxacin in pregnant and lactating women have not been established.
The drug should be used only after taking into account the benefits offered and the potential risks involved.
As with other drugs of this class, ciprofloxacin has been shown to cause arthropathy in weight-bearing joints of immature animals. Hence ciprofloxacin is usually not recommended for use in children.
In Impaired Renal Function:
If creatinine clearance is less than 20 ml/min, half the recommended dosage may be administered.
CNS stimulation: Ciprofloxacin should be used with caution in patients with CNS disorders such as severe cerebral arteriosclerosis or epilepsy.
Crystalluria: Inadequate intake of water, when on ciprofloxacin, can cause crystalluria.
Phototoxicity: Moderate to severe phototoxicity manifested by an exaggerated sunburn reaction has been observed in patients who are exposed to direct sunlight with some members of the quinolone class of drugs. Therapy should be discontinued if phototoxicity occurs.
Tendinopathy and Tendon Rupture: Fluoroquinolones, including CIPRO, are associated with an increased risk of tendinitis and tendon rupture in all ages. This adverse reaction most frequently involves the Achilles tendon, and rupture of the Achilles tendon may require surgical repair. Tendinitis and tendon rupture in the rotator cuff (the shoulder), the hand, the biceps, the thumb, and other tendon sites have also been reported.
Other generic forms are Ciloxan, Proquin Baycip, Ciloxan, Ciflox, Cipro XL, Ciproxin, Prociflor, or Proquin.
Ciplox tablets should be swallowed whole with adequate amount of liquid. Ciplox tablets can be taken without or without meals.Antacids should not be taken concomitantly or within two hours of dosing. Below are given the recommended adult dosage for various indications:
Respiratory tract, bone and joint infections:
Mild/moderate 500 mg twice daily/or 1000 mg once daily
Severe/complicated 750 mg twice daily
Urinary tract infections:
Acute uncomplicated 500 mg od for 3 days
Mild/moderate 250 mg twice daily / 500 mg once daily
Severe/complicated 500 mg twice daily/or 1000 mg once daily
Mild/moderate/severe 500 mg twice daily/or 1000 mg once daily
250 mg single dose
750 mg twice daily
500 mg twice daily/1000 mg once daily
500-750 mg twice daily
Chronic Bacterial prostatitis: 1000 mg once daily for 28 days
Ciprofloxacin (Ciplox) is generally well tolerated. Ciprofloxacin was discontinued because of an adverse effect in 1.0% of patients that were treated orally. The most common side effects are Nausea, Diarrhea , vomiting, liver function tests abnormal, abdominal pain, headache, restlessness and rash.
Other side effects which have been reported very rarely in less than 1% of ciprofloxacin patients include myalgia, tendonitis/rupture, exacerbation of myasthenia gravis, increases in serum transaminase levels, foot pain, palpitation, atrial flutter, ventricular ectopy, syncope, hypertension, angina pectoris, myocardial infarction, cardiopulmonary arrest, cerebral thrombosis, phlebitis, tachycardia, migraine, hypotension, restlessness, dizziness, lightheadedness, insomnia, nightmares, hallucinations, manic reaction, irritability, tremor, ataxia, convulsive seizures, lethargy, drowsiness, weakness, malaise, anorexia, phobia, depersonalization, depression, paresthesia, abnormal gait, grand mal convulsion,painful oral mucosa, oral candidiasis, dysphagia, intestinal perforation, gastrointestinal bleeding, cholestatic jaundice, hepatitis, lymphadenopathy, petechia, amylase increase, lipase increase, arthralgia or back pain, joint stiffness, achiness, neck or chest pain,flare up of gout,interstitial nephritis, nephritis, renal failure, polyuria, urinary retention, urethral bleeding, vaginitis, acidosis, breast pain, dyspnea, epistaxis, laryngeal or pulmonary edema, hiccough, hemoptysis, bronchospasm, pulmonary embolism, allergic reaction, pruritus, urticaria, photosensitivity/phototoxicity reaction, flushing, fever, chills, angioedema, edema of the face, neck, lips, conjunctivae or hands, cutaneous candidiasis, hyperpigmentation, erythema nodosum, sweating, blurred vision, disturbed vision (change in color perception, overbrightness of lights), decreased visual acuity, diplopia, eye pain, tinnitus, hearing loss, bad taste and chromatopsia.