Flagyl Tablets - Active Ingredient

The active ingredient contained in Flagyl Tablets is Metronidazole. Flagyl Tablets is used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.

Generic Forms and Brand names of Metronidazole

Flagyl Tablets manufactured by Abbott Healthcare Pvt Ltd, India is an effective treatment for bacterial and amebic infections. Flagyl which has the active ingredient Metronidazole is also sold as Metronidazole, Nidagyl, Mepagyl, RTU, Metro I.V., Protostat, Flagyl I.V. , Metryl and under various other brand names. Flagyl tablets contain 200 mg or 400 mg of metronidazole USP.

Preparations

Flagyl is available as tablets of 200 mg, 400 mg .

Flagyl Tablets - Uses

Flagyl Tablets (Metronidazole) are used for the treatment of the following infections:
Symptomatic Trichomoniasis:
Flagyl Tablets are indicated for the treatment of symptomatic trichomoniasis in females and males when the presence of the trichomonad has been confirmed by appropriate laboratory procedures such as wet smears and/or cultures.
Asymptomatic Trichomoniasis:
Flagyl Tablets are indicated in the treatment of asymptomatic females when the organism is associated with endocervicitis, cervicitis, or cervical erosion. Since there is evidence that presence of the trichomonad can interfere with accurate assessment of abnormal cytological smears, additional smears should be performed after eradication of the parasite.
Treatment of Asymptomatic Consorts: T. vaginalis infection is a venereal disease. Therefore, asymptomatic sexual partners of treated patients should be treated simultaneously with Flagyl Tablets if the organism has been found to be present, in order to prevent reinfection of the partner.
Although the decision to treat an male partner who has a negative culture or for whom no culture has been attempted and displays no symptoms of infection is an individual one, there is evidence that a woman may become reinfected if her consort is not treated. In any case, the consort should be treated with Metronidazole (Flagyl Tablets) in cases of reinfection.
Amebiasis:
Flagyl Tablets are indicated in the treatment of acute intestinal amebiasis (amebic dysentery) and amebic liver abscess. In amebic liver abscess, Flagyl therapy does not do away with the necessity for drainage of pus.
Anaerobic Bacterial Infections:
Flagyl is indicated in the treatment of serious infections caused by susceptible anaerobic bacteria. Indicated surgical procedures should be performed in conjunction with Metronidazole therapy. In the event of a mixed aerobic and anaerobic infection, antimicrobials appropriate for the treatment of the aerobic infection have to be used in addition to Metronidazole (Flagyl) therapy. Some of the anaerobic bacterial infections are given below:
Intra-Abdominal Infections that include peritonitis, intra-abdominal abscess, and liver abscess
Skin And Skin Structure Infections caused by Bacteroides species
Gynecologic Infections which include endometritis, endomyometritis, tubo-ovarian abscess, and postsurgical vaginal cuff infection
Bacterial Septicemia caused by Bacteroides species
Bone And Joint Infections as adjunctive therapy, caused by Bacteroides species
Central Nervous System (CNS) Infections that include meningitis and brain abscess
Lower Respiratory Tract Infections, including pneumonia, empyema, and lung abscess, caused by Bacteroides species
Endocarditis which is caused by Bacteroides species

Flagyl Tablets - Storage Requirements

Flagyl Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.

Flagyl Tablets - Dosage

The dosage of Flagyl tablets for certain indications is given below. The dosage should be individualized as per the requirement of the individual patient. Please consult your doctor for exact dosing instructions.
Trichomoniasis:
In Female Adult Patients:
One-day treatment - two grams of Flagyl, given either as a single dose or in two divided doses of one gram each, given in the same day.
Seven-day course of treatment - 250 mg three times daily for seven consecutive days.
Pregnant patients should not be treated during the first trimester.
Controlled comparative studies have indicated that cure rates as determined by vaginal smears and signs and symptoms, may be higher after a seven day course of treatment than after a one day Flagyl therapy.
Amebiasis:
Recommended Adults Dosage:
For acute intestinal amebiasis (acute amebic dysentery): 750 mg of Metronidazole orally three times daily for 5 to 10 days.
For amebic liver abscess: 500 mg or 750 mg orally three times daily for 5 to 10 days.
Pediatric patients: 35 to 50 mg/kg/24 hours, divided into three doses, orally for 10 days.
Anaerobic Bacterial Infections:
In the treatment of most serious anaerobic infections, FLAGYL I.V. (metronidazole hydrochloride) or FLAGYL I.V. RTU® (metronidazole) is usually administered initially.
The usual adult oral dosage is 7.5 mg/kg every six hours (approx. 500 mg for a 70-kg adult). A maximum of 4 g should not be exceeded during a 24-hour period. The usual duration of therapy is 7 to 10 days; however, infections of the bone and joint, lower respiratory tract, and endocardium may require longer treatment.

Flagyl Tablets (Metronidazole) - Contraindications

Flagyl Tablets are contraindicated in individuals with a hypersensitivity to metronidazole or other nitroimidazole derivatives or any other inactive ingredient present in Flagyl Tablets. Flagyl (Metronidazole) is also contraindicated in female patients with trichomoniasis during the first trimester of pregnancy.

Side Effects Of Flagyl Tablets (Metronidazole)

The most serious adverse reactions reported in patients treated with Flagyl (metronidazole) have been convulsive seizures, encephalopathy, aseptic meningitis, optic and peripheral neuropathy (which is characterized mainly by numbness or paresthesia of an extremity).The most common side effects of are nausea reported by about 12% of patients, sometimes accompanied by headache, anorexia, and occasionally vomiting; diarrhea; epigastric distress; and abdominal cramping. Constipation has also been reported. As persistent peripheral neuropathy has been reported in some patients that receive prolonged administration of Flagyl, patients should be told to stop the medicine and report immediately to their doctor if any neurologic symptoms occur.

Further Information

Prescribing Information